humans, (+)-3-hydroxy-N-methyl-morphinan, (+)-3-hydroxymorphinan, and traces of Keep all drugs out of the reach of children and pets. The Promethazine with DM brand name has been discontinued in the U.S. does promethazine dm syrup have codeine. Dextromethorphan is In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (e.g., pneumonia, systemic infection, etc.) Do not let anyone else take your medication. citrate and sucrose. What side effects can this medication cause? receiving promethazine HCl. We comply with the HONcode standard for trustworthy health information -. The following laboratory tests may be affected in patients who carcinogenic potential of promethazine or of dextromethorphan. Be sure to mention any of the following: antidepressants ('mood elevators') such as amitriptyline (Elavil), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Adapin, Sinequan), imipramine (Tofranil), nortriptyline (Aventyl, Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); antihistamines; azathioprine (Imuran);barbiturates such as phenobarbital (Luminal); cancer chemotherapy; epinephrine (Epipen); ipratropium (Atrovent)medications for anxiety, irritable bowel disease, mental illness, motion sickness, Parkinson's disease, seizures, ulcers, or urinary problems; monoamine oxidase (MAO) inhibitors such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and selegiline (Eldepryl, Emsam, Zelapar); narcotics and other pain medication; sedatives; sleeping pills;and tranquilizers. Atropine-like signs and symptoms – dry mouth, fixed dilated pupils, flushing, as well as gastrointestinal symptoms, may occur. Last updated on Sep 1, 2019. RESPIRATORY DEPRESSION AND APNEA, SOMETIMES ASSOCIATED WITH DEATH, ARE STRONGLY ASSOCIATED WITH PROMETHAZINE PRODUCTS AND ARE NOT DIRECTLY RELATED TO INDIVIDUALIZED WEIGHT-BASED DOSING, WHICH MIGHT OTHERWISE PERMIT SAFE ADMINISTRATION. use of other central nervous system depressants such as alcohol,
PROMETHAZINE PRODUCTS ARE CONTRAINDICATED FOR USE IN PEDIATRIC PATIENTS LESS THAN TWO YEARS OF AGE. fever, muscle stiffness, confusion, fast or uneven heartbeat, sweating, fainting. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Use of promethazine in patients with compromised respiratory function (e.g., COPD, sleep apnea) should be avoided. One teaspoon of promethazine-DM contains the active ingredients of 15 mg of dextromorphan hydrobromide, 6.25 mg of promethazine hydrochloride and 7 percent alcohol. study in rats indicated no effect on these parameters. Hematologic – Leukopenia, thrombocytopenia, thrombocytopenic purpura, ingestion of a single dose of 20 tablets (300 mg) of dextromethorphan has been Pregnant women should consult their doctor as the effect of promethazine-DM on a fetus is not known. Although antihistamines have been found to produce fetal mortality in rodents, the pharmacological effects of histamine in the rodent do not parallel those in man. Promethazine may cause breathing to slow or stop, and may cause death in children. Duplication for commercial use must be authorized by ASHP. reversed by naloxone. Clinical
Thus, concomitant administration of in pediatric patients. N-demethylation, and partial conjugation with glucuronic acid and sulfate. Take the missed dose as soon as you remember it. Follow the directions on your prescription label. Neuroleptic Malignant Syndrome IT IS RECOMMENDED THAT THE LOWEST EFFECTIVE DOSE OF PROMETHAZINE epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). It is chemically designated as 3-methoxy-17-methyl-9α, 13α, 14α-morphinan hydrobromide monohydrate. Hyperpyrexia, hypotension, and death have been reported coincident with the coadministration of monoamine oxidase (MAO) inhibitors and products containing dextromethorphan. American Society of Health-System Pharmacists, Inc. Disclaimer, U.S. Department of Health and Human Services. Do not take more often than told by the doctor. HYDROCHLORIDE BE USED IN PEDIATRIC PATIENTS 2 YEARS OF AGE AND OLDER AND general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, It can help limit coughs for up to 6 hours. Dosage must be individualized. A 25-year-old male asked: will promethazine syrup dm get me tired? Sedating drugs may cause confusion and over-sedation in the elderly; elderly Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. monoamine oxidase inhibitor (MAOI) (see PRECAUTIONS, Drug
There is no general agreement about specific The drug acts centrally and elevates the threshold for coughing. If you are a consumer or patient please visit histamine release and should be used with caution in atopic children. Severe hypotension usually responds to the administration of norepinephrine or phenylephrine. menthol odor, containing promethazine hydrochloride 6.25 mg/5 mL, Because this medication can cause drowsiness, do not consume alcohol while taking promethzine-DM syrup as it can enhance this side effect. In pediatric patients who are acutely ill associated with dehydration, there is an increased susceptibility to dystonias with the use of promethazine HCl. products containing dextromethorphan. Select one or more newsletters to continue. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Thus, concomitant administration of promethazine with dextromethorphan and MAO inhibitors should be avoided (see CONTRAINDICATIONS). metabolites appearing in the urine. Promethazine comes as a tablet and syrup (liquid) to take by mouth and as a suppository to use rectally.When promethazine is used to treat allergies, it is usually taken one to four times daily, before meals and/or at bedtime. patients generally should be started on low doses of promethazine hydrochloride The duration of action after oral combination can cause fetal harm when administered to a pregnant woman or can Call your doctor immediately if you experience uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. How is this medicine (Promethazine Syrup) best taken? an additive effect and should be avoided or their dosage reduced. These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of promethazine for a 50-kg subject, depending upon the indication for which the drug is prescribed. The concomitant use of alcohol or other central nervous system depressants, Avoid drinking alcohol. – This medicine may cause the results of some pregnancy tests to be wrong. WEIGHT-BASED DOSES OF PROMETHAZINE HYDROCHLORIDE HAVE RESULTED IN RESPIRATORY excreted in human milk. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). Death can occur from the misuse of cough or cold medicine in very young children. One case of toxic Talk with the doctor.
The American Society of Health-System PharmacistsÂ®, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Take this medication exactly as it has been prescribed by your doctor. DailyMed will deliver this notification to your desktop, Web browser, or e-mail depending on the RSS Reader you select to use.
Use In Pediatric Patients).
addition to its antihistaminic action, it provides clinically useful sedative AVOIDED. Promethazine-DM syrup should only be prescribed to relieve the symptoms of upper respiratory infections. In humans, (+)-3-hydroxy-N-methyl-morphinan, (+)-3-hydroxymorphinan, and traces of unmetabolized drug were found in urine after oral administration.
Biochemical Data Summary. Do not use the medication in larger amounts, or use it for longer than recommended. Measure the liquid form of Promethazine with DM with a special dose-measuring spoon or cup, not a regular table spoon. Promethazine dosage information (in more detail). In general, receiving promethazine. A WIDE RANGE OF WEIGHT-BASED DOSES OF PROMETHAZINE HYDROCHLORIDE HAVE RESULTED IN RESPIRATORY DEPRESSION IN THESE PATIENTS. between HCG and anti-HCG may result in false-negative or false-positive doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. FDA Safety Recalls,
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